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The Concentration-Effect RelationshipInhibiting Sweat Glands and Sweating As with many drug therapies, the active ingredient in pharmaceutical formulations can exhibit a concentration-effect or dose-response relationship. Quite simply, as you increase the concentration of the active ingredient, you see a corresponding increase in its therapeutic effect. This is exactly the case for the active ingredient in DryDerm. The line graph below demonstrates that as the concentration of aluminum chloride hexahydrate increases, the percentage of sweat glands that are inhibited also increases, resulting in less sweating.
*Adapted from Dermatopharmacology of Topical Preparations by B. Gabard et.al. (Eds.) Springer Verlag, 2000
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All of this sounds very logical, but there are many instances when a drug can 'plateau'. In other words, after a certain concentration is reached there is no longer any increase in therapeutic effect. In this case, adding more drug does not result is a greater response.
The active ingredient in DryDerm does not plateau and this is the reason we offer a variety of product strengths. Although it may be tempting to treat an excessive sweating condition with the highest strength, this is not recommended. First of all, although higher strengths may be more effective, they are also more likely to cause skin irritation. Secondly, it does not make good medical sense to treat a hyperhidrosis condition with a high strength formulation (e.g. DryDern 35) when a lower strength version will suffice (e.g. DryDerm 20). You do not need a brick to kill a fly - a simple swatter will do the job. |