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Glycopyrrrolate - How it Works and How to UseGlycopyrrolate (a.k.a. Robinul) is the principle or active ingredient in DryDerm G wipes. Several clinical studies have shown that it very effective in treating gustatory hyperhidrosis or sweating. But how exactly does it work to achieve these results is a good question. Following is a description of how it does so. First of all, we need to understand that sweat glands are innervated. In other words, each sweat gland will have tiny nerve endings associated with it. These nerve endings will either be somewhat 'dormant' or will stimulate the sweat gland to produce and secrete sweat. Ultimately, a region in the brain is responsible for sending an 'on or off' signal depending on whether or not there is an increase in body temperature (see Mechanism Behind Sweating page).
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While an increase in body temperature is the usual process that triggers the brain to send signals to the sweat gland, in gustatory sweating, that trigger is certain foods. So-called 'culprits foods' fool a specific region of the brain to send 'ON' signals to the sweat glands found in the facial region. And so, glycopyrrolate blocks that part of the nerve signal that stimulates the sweat glands to produce sweat. Nerve signals are transmitted from nerve to nerve or from nerve to end-organ (e.g. sweat glands) via the release of neurotransmitters. Glycopyrrolate blocks the release of the neurotransmitters and as a result, the signal becomes attenuated. A dimished or lack of signal results in a reduction in the production and secretion of sweat.
DryDerm G wipes.
For gustatory sweating and compensatory sweating Available in 1% and 2% strengths
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Using DryDerm G - Directions and Precautions
1. Wipe affected area and do not wash treated area for at least 4 hours - cosmetics and creams can be applied after DryDerm G has dried 2. AVOID applying to mouth/lips, eyes, or mucous membranes. - contact lens users: insert contact lens before using DryDerm G or wash hands thoroughly before inserting lens 3. Do not apply to open wounds, cuts, broken skin 4. Discontinue if a rash or skin irritation develops 5. Be sure to close container firmly to avoid evaporation and drying of wipes - Keep out of reach from children and pets 6. Wash hands after use 7. DO NOT use DryDerm G if you have glaucoma, bladder obstruction, rapid heart rate, or if you are allegic to glycopyrrolate. Do not use if pregnant or breast feeding. |