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Iontophoresis Solutions - Clinical Results
Aluminum Chloride Hexahydrate 1% SolutionIn this study*, subjects were treated for 4 consecutive days and sweating rates were evaluated pre-treatment as well as 3 days, 1, 2, 3 and 4 weeks after treatment. The chart below shows the sweating rates as a percent of baseline or pre-treatment sweating.
The chart demonstrates that over the period of a month, sweating rates have a tendency to return to pre-treatment levels. What should be noted is the return to pre-treatment levels is much slower in the subjects that used the 1% AlClHex iontophoresis solution (grey bars). Furthermore, after one month, these patients had sweating return to less than 60% of pre-treatment levels. *Kalantari, KK, et.al. Iran.J.Pharm.Res. 2011 **Dolianatis, C, et. al. Austr. J. Dermatol. 2004
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Glycopyrrolate 0.05% Solution
This study** involved 20 individuals with palmoplantar hyperhidrosis (18 severe, 2 moderate) and demonstrated that using glycopyrrolate solution for iontophoresis increased significantly the numbers of post-treatment dry days compared to tap water. More specifically, the number of dry days ranged from 0 to 15 and 0 to 31 for tap water (TW) and glycopyrrolate (GLP) respectively. Median number of dry days following treatment were 3 days for TW and 11 for GLP. Duration of symptom relief with GLP
in weeks |
Iontophoresis is not for Everyone
Contraindications to glycoyrrolate or aluminum chloride hexahydrate iontophoresis include:
Contraindications to glycoyrrolate or aluminum chloride hexahydrate iontophoresis include:
- Pregnancy
- Past history of cardiac arrhythmia
- Cardiac pacemaker
- Narrow angle glaucoma
- Metallic implants such as intrauterine contraceptive devices and orthopaedic prostheses