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More on Sweat Glands Sweat glands (1.6–5 million) are distributed over the whole body surface with an average density of 200 sweat glands per square centimeter.
A recent study showed the highest sweat gland density can be found on the palms and soles and the least on the back. The palms have been shown to have up to 700 glands per square centimeter. For those not used to the metric system - there are about two and a half centimeter per inch (or about 1800 glands per square inch).
View our video on why sweat is salty
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Although sweat glands appear simple in structure and function, they are relatively complex little structures. We mentioned that they play an essential role in the regulation of body temperature or thermoregulation. They may also have evolved with a role of providing the body a mechanism to fight superficial bacterial infections. See More on perspiration tab.
Sweat glands do more than just pump out sweat. They also adjust the chemical components found in perspiration. This process is done as the sweat moves to the surface of the skin. It normally removes salt. In individuals with cystic fibrosis (CF), this mechanism is faulty. As a result, the sweat is saltier than normal. The high concentration of salt in individuals with CF has played a key role in the diagnosis of CF. Some 400 years ago, a professor of medicine in Spain first described the salty taste of infants with cystic fibrosis. He wrote that is was known that the fingers tasted salty after rubbing the forehead of the bewitched child*. Sweat glands have played a key role in our understanding of CF. * Alonso y de los Ruyzes de Fonteca J. Diez Previlegios para Mugeres Prenadas. Henares, Spain, 1606. ** Wilke, K.,
Keil, F.J., Wittern, K.P. et al.
Immunolabelling
is essential
for the differentiation of human axillary
apoeccrine glands. J. Invest. Dermatol. 123, A93 (2004).
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