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Resistant Palmoplantar Hyperhidrosis
Sweaty palms and/or soles can be especially difficult to treat. Topical treatments such as DryDerm PP may only provide a partial response and may fall short of expectations. In such cases, consider combination therapy. In other words, adding a second treatment may provide the added response you are looking for.
You may want to consider adding a treatment called iontophoresis. Typically, iontophoresis is done using tap water. Keep in mind that if you live in an area that provides so-called 'soft' water (as opposed to 'hard'), the treatment may be less effective. Salt can be added to render a more effective solution.
The Advantage of Combination Therapy
Two separate studies* using combination therapy (i.e. iontophoresis with glycoyrrolate solution & topical aluminum chloride) demonstrated that remission periods are elongated significantly. One study resulted in a remission of symptoms for an average of 20 days vs 3.5 days for tap water iontophoresis alone. Another study averaged a 32-day remission period using combination therapy.
*Shen JL, et.al. A new strategy of iontophoresis for hyperhidrosis. J Am Acad Dermatol. 1990
Combining DryDerm and Iontophoresis
Combining a topical treatment such as DryDerm PP to iontophoresis may just be enough to treat stubborn or resistant cases of palmoplantar hyperhidrosis. Best of all, the combination treatment remains topical, non-invasive, needle-free, and relatively inexpensive. Granted, the cost of materials for iontophoresis is a significant expense, it is a one-time cost that is usually spread over a long period of time.
Combination treatment can be a little hectic initially - treating with iontophoresis during the day and DryDerm at night, but the frequency of treatments will decrease after a few sessions. Consider continuing DryDerm PP between treatments of iontophoresis to minimize their frequency.
The efficacy of iontophoresis can be further enhanced (go to Iontophoresis Solutions - study results) by adding glycopyrrolate (GLY) or aluminum chloride hexahydrate (ACH) to the water. For example, ACH solution has been shown to provide lasting relief, increasing time between treatments. Ultimately this means longer lasting results and fewer treatments.